PATHWAY OPTIONS
There are a number of choices. Please ensure you select the correct pathway for your sample. Please give as much clinical detail as possible on all samples.
- Pathway 5A: CML new: BLOOD
- Pathway 5B: CML new: BLOOD (rapid test)
- Pathway 5C: CML new: MARROW (full diagnosis)
Pathway 5A: CML new: BLOOD
Use this pathway for molecular testing to exclude a diagnosis of CML in cases with an elevated white count where diagnosis is not considered urgent.
The following tests will be performed:
- Morphology blood
- Molecular (RNA) for BCR::ABL1
Pathway 5B: CML new: BLOOD (rapid test)
Use this pathway for urgent investigation where treatment may be required immediately (Rapid FISH) this can allow treatment initiation pending a full marrow assessment.
The following tests will be performed:
- Morphology blood: URGENT
- Molecular (RNA) for BCR/ABL1
- Cytogenetics/FISH CML [URGENT]
Pathway 5C: CML new: MARROW (full diagnosis)
Use for full evaluation of CML diagnosed or suspected following blood investigation.
- Morphology marrow: URGENT
- Flow cytometry (exclude acute leukaemia)
- Bone marrow trephine
- Cytogenetics/FISH CML [URGENT]
- Molecular (RNA BCR/ABL1)
- OPTION Molecular (DNA) hold and analyse on specific physician request