HCDP Manchester

MDS or CMML (new or follow up)

PATHWAY OPTIONS
There are a number of choices. Please ensure you select the correct pathway for your sample. Please give as much clinical detail as possible for all samples.

Pathway 7A: Suspected myelodysplasia diagnosis

Use for new cases with high suspicion of MDS based on clinical assessment. A myeloid panel will be processed, an RNA sample will be held for processing if indicated (e.g. failed cytogenetic testing or unanticipated acute leukaemia).
The following tests will be performed:

  • Morphology with iron stain
  • Flow cytometry (for blast cell assessment)
  • Trephine
  • Cytogenetics myeloid disorder
  • Molecular myeloid panel
  • Molecular RNA sample (store)

Pathway 7B: Suspected CMML diagnosis

Use for cases with high suspicion based on clinical or morphological testing and where a monocytosis suggests a diagnosis of CMML is likely. Please supply details of monocytosis and ideally a peripheral blood film.
The following tests will be performed:

  • Morphology with iron stain
  • Flow cytometry (for blast cell assessment)
  • Trephine
  • Cytogenetics myeloid disorder
  • Molecular myeloid panel
  • Molecular RNA sample (store)

Pathway 7C: Myelodysplasia/ CMML follow up (basic set)

Use for known cases of known MDS/ CLL where a limited disease reassessment is required.
The following tests will be performed:

  • Morphology
  • Flow cytometry (for blast cell assessment)
  • Trephine

Pathway 7D: Myelodysplasia/ CMML follow up (full set)

Use for known cases of known CMML where clinical features or treatment requires disease re-assessment.
The following tests will be performed:

  • Morphology with iron stain
  • Flow cytometry (for blast cell assessment)
  • Trephine
  • Cytogenetics myeloid disorder
  • Molecular myeloid panel
  • Molecular RNA sample (store)